Alaska Airlines has announced it will launch daily nonstop service between San Luis Obispo County Regional Airport and San Diego International Airport on January 7, 2020, and San Luis Obispo Regional Airport and Portland International Airport on June 18, 2020.
| Effective Date | City Pair | Departs | Arrives | Frequency | Aircraft |
| Jan. 7, 2020 | San Diego – San Luis Obispo | 11:55 a.m. | 1:07 p.m. | Daily | E175 |
| Jan. 7, 2020 | San Luis Obispo – San Diego | 1:50 p.m. | 2:57 p.m. | Daily | E175 |
| June 18, 2020 | Portland – San Luis Obispo | 1:10 p.m. | 3:18 p.m. | Daily | E175 |
| June 18, 2020 | San Luis Obispo – Portland | 3:55 p.m. | 6:03 p.m. | Daily | E175 |
Alaska will operate once daily nonstop service between San Luis Obispo and San Diego, and between San Luis Obispo and Portland, Oregon.